The best treatment for a hard knock on the head might someday involve a quick sniff of a nasal spray. Researchers have found early evidence in mice that an antibody-based treatment delivered up the nose can reduce the brain damage caused by concussions and more serious traumatic injuries.
Scientists at Mass General Brigham conducted the study, published Thursday in Nature Neuroscience. In brain-injured mice, the experimental spray appeared to improve the brain’s natural acute healing process while also reducing damaging inflammation later on. The findings could lead to a genuine prophylactic against the long-term impacts of traumatic brain injuries and other conditions like stroke, the researchers say.
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Foralumab, developed by the company Tiziana Life Sciences, targets a specific group of proteins that interact with the brain’s immune cells, called CD3. This suppression of CD3, the team’s earlier work has suggested, increases the activity of certain immune cells known as regulatory T cells (Treg). As the name implies, these cells help regulate the brain’s immune response to make sure it doesn’t go haywire.
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n their latest mice study, the researchers found that foralumab—via the increased activity of Treg cells—improved aspects of the brain’s immediate healing from a traumatic injury. The dosed mice’s microglia (the brain’s unique first line of immune defense) became better at eating and cleaning up after damaged cells, for instance. Afterward, the drug also appeared to prevent microglia from becoming chronically inflamed, As a result, relative to mice in a control group, mice treated with foralumab up to three days post-injury experienced greater improvements in their motor function and coordination.
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Source: A Nasal Spray for Concussions Shows Early Promise
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